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Sleep Wake Nutrient Detoxification Protocol
Post Covid-19 Infection
To: Michelle Luttrell, R.N., MSN, N.P., Sutter Health, Institute for Health and Healing{source} From: Daniel Lappin; This email address is being protected from spambots. You need JavaScript enabled to view it. RE: Swift reduction of sleep symptoms due to night time/day time detoxification nutrient protocol, post Covid-19 infection. Version date: January 25, 2023
p. 1 Acknowledgements,Disclaimer, Legal agreement.
p. 2
Introduction: Novel Interoception Method Sparks Break-Through.
Warning Definition: Toxic, Detoxify Hypothesis: Detoxification supports sleep outcomes Summary of Protocol Solutions and Benefits
p. 4 Sleep Detoxification Nutrients .vs. Sleep Promoting Nutrients Potential Applications
p. 5 Case study description and results
p. 6 Novel mind-body technique revealed innovative solution Results by week
p. 7 8-Steps of the protocol
p. 8 Detoxification nutrient: Standard dose
p. 9 Detoxification nutrient: Pre-sleep dose Acid/Alkaline: Bicarbonate salts Lab Tests: No Disruption from Large Nutrient Intake, week 8
p. 10 Future Overnight Sleep Study Help other people overcome sleep problems: Please give feedback Bitter Herbs added to protocol, week 12
p .11. Potential Value of detoxification protocol to Obstructive Sleep Apnea and Long Covid
p. 12 Sleep Health Resources, General Discussion Regarding the dosage of Ketotifen, the Mast Cell Stabilizing Drug.
P. 13 Potential Value of detoxification protocol to Obstructive Sleep Apnea and Long Covid
Acknowledgements: Without the support of the following physicians, nurses and staff, it would not have been possible for me to create the novel treatment solutions describe below. With much appreciation to:
Disclaimer: The following information is not a substitute for a consultation with a qualified nutritionist, physician, or healthcare practitioner trained in relevant mechanisms. This document is for educational purpose only. This document does not diagnose or treat any health, medical or mental health condition that you may have. By reading this document you agree that if you attempt this protocol you do so at your own risk.
Legal Disclaimer and agreement
This document is written by Daniel Lappin. It has not been reviewed by, nor is approaved by the following: Sutter Health, Sutter Health Institure for Health and Healing, the University of California San Francisco Sleep Medicine Department, nor any of the individual health care practitioners acknowledged in this document.
By reading this document you agree to:
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Introduction: Novel Interoception Method Sparks Break-Through.
Based upon current physician consultation and historical medical records, in his early and mid-teens, Mr Lappin was plagued with apparentl bacterial and viral infections. Apparently causing a burden to his immune system, during a sporting event at age 16 he collapsed, in what may have been the first event of a mast cell activation disorder. This began decades of health difficulties, apparently centered around intermitte neuro-brain inflammation.
Unknown at the time, he had been born with a genetic polymorphisms (gene alterations) relating to the detoxification mechanism in his body, such as teh COMT gene. This detoxification problem combined with recurrant bacterial and viral infections created a difficult and confusing life-long health condition.
After years roller coaster health, waves of collapse and recovery, and slow improvement, he contracted Covid-19 in May of 2022. It was a difficult setback, causing increased sensitivity and dis-regulation in sleep, digestion, mood, stress regulation, and social engagement, and cognitive function.
These Covid-19 difficulties persisted through to September of 2022, when a fortuitous event occurred.
An overnight sleep study (Yuen) identified a significant low measure in the N3 sleep phase, where glial cell brain detoxification occurred. This gave hard data of his brain state. This potentially was a measure of a toxic load in his brain that could be triggering an inflammatory response and contributing to Obstructive Sleep Apnea symptoms (Yuen). Secondly, in that same period of time he had a consultation with Dr. Babak Kanani on detoxification nutrients.
Taking this two pieces of information information, Mr. Lappin engaged in a practice he had cultivated for many years – a distinct of distinct, self-reflective, physiology based inquiry. In general, this form of internal physiology awareness has been labeled by the National Institute of Health as “Interoception”.
Using this Interoception process he pulled an idea out of thin air – increase his current detoxification nutrients dosage from one to seven times per day, consuming them during the day and at wake points in the middle of the night, for a total increase of approximately 700%. A mega-dose of detox nutrients.
This created a breakthrough.
Within a few weeks of this protocol, as described below, 80-90% of his difficult sleep symptoms were gone. A reprieve he had struggled with for decades.
This reinforced and elevated the conclusion that he suffers from an underlying genetic polymorphism relating to detoxification genes .
Note: After the sleep nutrient protocol was initiated, no other forms of new therapies (herbals, vitamins, drugs) were introduced into Mr. Lappin’s regiment.
Interoception, See: We've Lost Touch with Our Bodies; Scientific American, Feb. 5, 2019 https://blogs.scientificamerican.com/observations/weve-lost-touch-with-our-bodies/ NCCIH’s Hot Topic Webinar on July 15: Probing Interoceptive Processes: Join NCCIH’s Hot Topic Webinar on July 15https://www.nccih.nih.gov/research/blog/probing-interoceptive-processes-join-nccihs-hot-topic-webinar-on-july-15The Science of Interoception: an NIH Blueprint for Neuroscience Research Workshop: The Science of Interoception and Its Roles in Nervous System Disorders
Warning:
Consuming large quantities of nutrients may be harmful to your health. Consult your appropriate medical or health practitioner to discuss your specific needs and any risks specific to your condition
Definition: Toxic, Detoxify, Elimination There are many philosophies and methods to detoxify the body. The idea of ‘toxic’ and ‘detoxify’ vary across the disciplines within traditional western medicine, functional medicine, integrative health, and mental health.
In this document, the terms toxic and detoxify refer to:
Toxic: the normal waste material of the body.
Detoxify: the normal process of eliminating waste material from the body that occur during:
These toxic, detoxify Mechanisms relate to
The protocol in this document does not address or activate ‘detoxification’ processes to stimulate, or ‘flush’ the release of accumulated toxins from organs such as the liver and the lymphatic system. Nor, principles of detoxification related to alcoholism.
Hypothesis: Detoxification supports sleep outcomes
Summary: Hypothesis of Therapeutic Action
The success of the approach described in this document, may be due to:
Summary of Protocol Solutions and Benefits:
This document is a case report created by the patient, Daniel Lappin, who suffered for decades with profound sleep issues , including multi-hour sleep paralysis episodes, waking with symptoms that were described as pseudo-strokes, significant left side muscular-skeletal constriction, and transient and crippling levels of cognitive disruption. With support from a sleep physician and a functional medicine doctor, Mr. Lappin self-created the protocol described below.
Within weeks, decades of difficult sleep issues were virtually (80- 90%) gone.
The focus of this protocol is to support the normal mechanism of detoxification that occur from digestion, sleep and daily activity. This protocol does not address accumulated toxins in tissues of the body.
The central solution was to consume large doses of over-the-counter detoxification nutrients at multiples times:
Taking nutrients to support the body’s ability to detoxification during sleep, is a different tactic then taking nutrients to promote sleep, such as tryptophan or melatonin.
This document gives background information, plus details of the protocol Mr. Lappin implemented.
This is a case study of patient Daniel Lappin, who has an underlying genetic polymorphisms related to detoxification mechanisms of the body. This extreme nutrient protocol helped him, yet it may be excessive for you. Therefore:
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Sleep Detoxification Nutrients .vs. Sleep Promoting Nutrients
A common nutritional approach to sleep supports the mechanism that induce sleep, such as: - Tryptophan and melatonin
This nutritional approach supports the mechanism of detoxification. This potentially reduces inflammation and prevents disruptions to sleep; such as: Vitamin C, Quercetin, Co-Q10, zinc, magnesium. See the list below.
Potential Applications
To Discuss with your Physician or Qualified Health Practitioner
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Case Study Description and Results
The protocol described in this document is a custom solution created by Daniel Lappin for his personal condition. This protocol may not benefit you for you. You will need to customize this protocol to fit your needs.
Daniel was born with several genetic conditions/polymorphisms that effect his methylation (one of the detoxification mechanisms of the body) processes. Because of these polymorphisms his body becomes toxic easily and detoxifies slowly.
The recent success of this protocol suggests that Mr. Lappin symptoms were being caused, at least in part, by his body’s inability to detoxify from normal activities, such as eating and sleeping. Therefore, additional toxic loads, from a viral or bacterial infection, created additional, and at times significant, challenge and disrgulation to his body and brain. This appears to be the cause of the notable increase in symptoms he experienced after contracting Covid-19 in May, 2022.
This suggests that an extreme protocol described here is what is needed to address his complicated condition.
After years of slow progress to reverse his night time sleep issues, Daniel contracted Covid in May of 2022. His symptoms, including sleep disturbances, became notably worse.
Potentially, the increased Covid viral load increased the toxic burden to his body and the elimination channels. This may be a partial explanation for the increase in sleep symptoms following the Covid infection.
Mr. Lappin has been diagnosed with:
Daniel’s post-Covid infection symptoms included: waking 1 to 4 times a night, mild obstructive sleep apnea, multi-hours episodes of sleep paralysis, night time pseudo-strokes (shallow breath, left side muscles constrictions), disruption to motor function during sleep (described as abnormal involuntary movement), significant, sharp muscle pain and stiffness upon waking, gastro-intestinal difficulties, notable cognitive impairment upon waking, disruption to social engagement functioning.
Mr. Lappin received an overnight sleep study on August 23, 2022:
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Results by Week
Results week 3
The sleep symptoms were reduced by 90 % within three weeks of implementing the detox nutrient protocol.
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Results week 5
Achieved three nights of uninterrupted 7 to 8 hours of peaceful, restful sleep. Waking up once during night approximately 2-3 times per week. Episodes of sharp night time leg pain, reduced to 2 times per week, mild level
Week 6-7:
Week 14: Bitter Herbs added to the protocol
Historically, I have consumed bitter herbs to support my health. Yet for he past few years I used them less. In mid-December, approximately week 12 of the detox nutrient protocol,,I reintroduced bitter herbs into my diet. -with notable benefits. The herbs I added where Flora brand Swedish Bitters (non-alcohol, no sugar added) Rosemary essential oil. Administered as oral drops, 10-15 per day. Oil of Oregano
Combined, both of these herbs provided a digestive and cognitive jump start to my body and my brain. This included a nice stimulation to cognitive function.
Week 17: Change in fitness improves cognition; from Cardio Kickboxing to High Intensity Interval Training.
Historically, I have thrived on cardio fitness. Specifically dance and cardio-kick boxing. I needed this form of fitness because the frequent night time disruptions would cause constriction in my brain and imparir my cognition. Robust cardio fitness, would pump blood back into my brain and support all my functions.
After the success of the detoxification mega doses of detoxification nutrients, I was draw to try another form of training - HIIT - High Intensity Interval Training. To my delight, this form of training, short burst of intense, strength training, jump started my brain to another new level. After less then nine 45 minute HIIT group training classes, my brain is functioning at a higher, more consistent level. My physical strength and endurance are improved. Ccombined with improved stress regulation from the detox nugtrients, I feel substantially better than I did six months ago.
8 Steps of the protocol
Begin hydrating 2 hours prior to sleep. Drink as much as your body desires. 32 – 64 ounces is good.
Take ‘Pre sleep’ nutrient dose prior to sleep.
a. Take a ‘standard’ nutrient dose upon waking.
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Stages of Nutrient Dosages implementation
The nutrients consumed and the timing of their consumption changed as I gathered insight in to the benefits. It was a dynamic learngin journey.
Detoxification Nutrients: Standard Dose
The ‘Standard’ dose is taken:
The nutrients of the standard dose are:
Note: Mr. Lappin adds 0.5 Mg of Ketotifen and HI blocker and mast cell stabilizing drug at each of the standard dose to address underlying mast cell activation disorder.
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Detoxification Nutrient: Pre-Sleep Dose The pre-sleep dose contains all of the nutrients in the standard dose listed above, and adds these additional nutrients. This dose is taken only once, at pre sleep.
Standard dose, then add:
https://www.xymogen.com/formulas/products/6129
Acid/Alkaline: Bicarbonate salts
Alkala and Tri Salts Bicarbonate salts are unique in that the can either increase of decrease the pH level of the body as the body needs. In general they reduce acidity in the body.
They are often used during periods of intestinal gas to reduce the acidic state and its consequences.
Take 1/16th teaspoon or less and place in your mouth. Let it dissolve and absorb into your mouth. After a couple minutes ewither swallow or spit out.
Under conditions of toxicity, the elevated acidity can create fatigue. Taking a small amount of bicarbonate salts can help repair this state.
Bicarbonate products:
Pleo-Alkala https://www.naturalhealthyconcepts.com/pleo-alkala-powder.html
BioTEch Tri Salts
https://www.amazon.com/Cardiovascular-Research-Ecological-Formulas-Tri-Salts/dp/B00014DY5S
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Lab Tests: No Disruption from Large Nutrient Intake, week 8
At week 8, a comprehensive metabolic panel was conducted out of concern that the high intake of nutrients might disrupt the biochemistry. These results were reviewed by Michelle Lutrelle CRNP, PCP.
All Lab results came back normal, and typical, with no concerns.
An additional comprehensive metabolic panel will be conducted in February 2023, to again check if the high nutrient dose is disrupting any important chemistry.
P. 11
Sleep Health & Resources
Sleep, and the disruption of sleep, are phenomena that have many factors. This document describes a small portion of sleep issues. Consequently, this protocol may or may not benefit you. Hopefully it does.
Here are a few resources to navigate the Covid sleep landscape:
Why sleep problems continue after COVID infection
For many people, sleep troubles don’t end on Day 10 or when a person tests negative. To gauge how often sleep troubles persist, researchers surveyed more than 650 long COVID patients who visited the Cleveland Clinic’s reCOVer Clinic between February 2021 and April 2022. Up to six months after an infection, 41 percent reported sleep disturbances; an additional 7 percent reported disturbances that were severe. Black patients, 12 percent of study participants, were three times more likely to report sleep problems compared with other groups—echoing disparities seen throughout the pandemic, says Cinthia Peña Orbea, a sleep specialist and lead author of the study, which was published in June.
Sleep Disturbances in Post-Acute Sequelae of COVID-19
https://academic.oup.com/sleep/article/45/Supplement
Regarding the dosage of Ketotifen, the Mast Cell Stabilizing Drug.
As the field of Mast Cell Activation is young. The public knowledge regarding mast cell dynamics and treatments is still new to the populaiotn, and new to some physicians.
The field of Mast Cell Activation is relevant due to the increase in general stress to the population. Increases in viral infections, that can increase the burden to the elimination channels of the body, and contribute irritants that can affect the Mast Cell Membrane. This can potentially trigger a Mast Cell release of its chemical messengers. This can then trigger immune system responses.
With the current sleep detoxification nutrient protocol, I am consuming 2.5 to 3.0 mg of Ketotifen, a mast cell activation stabilizing drug. This dosage is distributed across 5-6 doses per 24 hour period.
One question arises: to what extent , if any, are the improvements in my sleep and functional capacity caused by the quantity or distribution of the Mast Cell stabilizing drug?
The answer is uncertain.
In the past, I was taking a higher dosage of Ketotifen, 1.25 mg per dose. I was taking two to three of them per day. The totals 2.5 mg to 3.75 mg per day. During that period I did not achieve the improvements to sleep and function as I have with the significant increase to the detoxification nutrients.
Consequently, my conclusion is that the improvement to my condition is the result of the large doses of detoxification nutrients, not a change to the amount or timing of the mast cell drug Ketotifen. However, consuming 0.5 mg of ketotifen at multiple intervals may be adding benefit in some form.
P. 13
Potential Value of detoxification protocol to Obstructive Sleep Apnea and Long Covid
Might this N=1 case study be a data point of evidence that contributes to Complementary and Alternative Therapies for Obstructive Sleep Apnea and Long Covid sleep disruption?
NIH/NCCIH Sleep Disorders On the webpage of the National Institute for Complementary and Integrative Health (NCCIH) titled: Sleep Disorders: In Depth https://www.nccih.nih.gov/health/sleep-disorders-in-depth This NCCIH webpage does not address the solution achieved by this Lappin Case Study'. Consequently, this case study may provide a stepping stone of evidence to support further Complementary and Alternative therapies research in this area.
This case study supports the position that nutrient detoxification therapies can be applied to: - Treating the sleep disruption caused by a Covid-19 infection. - Treatment for obstructive sleep apnea. - Treatment for Mast Cell Activation Disorder
The nutrient protocol of this case study, in forms adaptable to the individual patient, may be a therapy more easily received by Obstructive Sleep Apnea (OSA) patients then a CPAP machine? Therefore, this general nutrient detoxification protocol may decrease the burden of OSA in the population.
Potential therapy for Sleep Disruption in Long Covid.
Recent research has documented the consequences of Covid-19 infection upon sleep patterns – one symptoms of long Covid. For many people, sleep troubles don’t end on Day 10 or when a person tests negative. To gauge how often sleep troubles persist, researchers surveyed more than 650 long COVID patients who visited the Cleveland Clinic’s reCOVer Clinic between February 2021 and April 2022. Up to six months after an infection, 41 percent reported sleep disturbances; an additional 7 percent reported disturbances that were severe. Black patients, 12 percent of study participants, were three times more likely to report sleep problems compared with other groups—echoing disparities seen throughout the pandemic, says Cinthia Peña Orbea, a sleep specialist and lead author of the study, which was published in June.
See: Covid 19 can ruin your sleep in many differet ways. - here's why. National Geographics, Nov, 11, 2022 See Link Here
Sleep Disturbances in Post-Acute Sequelae of COVID-19 https://academic.oup.com/sleep/article/45/Supplement
Might the data from the Lappin case study indicate a path for research to help resolve some long Covid sleep problems?
Help other people overcome sleep problems: Please give feedback
If you use some or all of this protocol, and achieve benefits, please send me a brief description of your experience. I will share your ‘de-identified’ (you will not be identified) story with the medical team that has supported me, so that they may share this protocol with others to reduce their sleep symptoms.
Thank you in advance, Daniel Send your story to: Daniel Lappin; This email address is being protected from spambots. You need JavaScript enabled to view it.
Copyright, Daniel J. Lappin, 2023. All rights reserved.
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